SupplementDuel

L-Citrulline

Amino Acid

Pre-workout staple for vasodilation and reduced muscle soreness. Raises plasma arginine more efficiently than arginine itself.

pumpendurancesorenessvasodilation
Typical dose
6–8 g pre-workout (citrulline malate 8 g)
Evidence
Moderate (some RCTs)
Onset time
Acute: 60 min
Half-life
~1 hour
Forms
Powder, Capsule
Source
microbial
Best taken with
water, empty stomach
Best time of day
pre-workout
Bioavailability
5/5
Safety rating
5/5
Price per serving
$0.65
Vegan / GF / 3rd-party
✓ / ✓ / ✓
Find L-CitrullineiHerb →

Vetted brands, third-party testing, ships worldwide.

Common uses

  • • Pre-workout pump
  • • Endurance
  • • Reduced DOMS

Effect profile

Strength
●●●○○
Muscle
●●●○○
Energy
●●●●○
Focus
●●○○○
Mood
●●○○○
Sleep
●○○○○
Immunity
●○○○○
Recovery
●●●○○
Longevity
●●○○○

Common side effects

  • • Generally none

Avoid if

  • • Severe hypotension
  • • Sildenafil interactions

Drug interactions

  • • Sildenafil
  • • Blood pressure meds

Related amino acid supplements

L-Citrulline vs BCAAL-Citrulline vs Essential Amino Acids (EAA)L-Citrulline vs L-GlutamineL-Citrulline vs L-Arginine

Medical disclaimer

SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements.