SupplementDuel

Phosphatidylserine

Nootropic

Cell membrane phospholipid that lowers cortisol and supports memory in aging. Particularly useful for stress-induced poor sleep.

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Typical dose
100–300 mg daily
Evidence
Moderate (some RCTs)
Onset time
Cumulative: 3–8 weeks
Half-life
—
Forms
Capsule, Softgel
Source
plant
Best taken with
with food
Best time of day
evening
Bioavailability
4/5
Safety rating
5/5
Price per serving
$0.80
Vegan / GF / 3rd-party
✓ / ✓ / ✓
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Common uses

  • • Memory in aging
  • • Cortisol management
  • • Sleep
  • • Athlete overtraining

Effect profile

Strength
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Muscle
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Energy
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Focus
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Mood
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Sleep
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Immunity
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Recovery
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Longevity
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Common side effects

  • • GI upset (high doses)

Avoid if

  • • Anticoagulants

Drug interactions

  • • Anticholinergics
  • • Anticoagulants

Related nootropic supplements

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Medical disclaimer

SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements.