Creatine Monohydrate vs Methylfolate (5-MTHF)
Creatine vs Vitamin · evidence-backed comparison
- • Creatine Monohydrate has the broader effect profile across the 9 effect categories.
- • Creatine Monohydrate is cheaper per serving ($0.15 vs $0.22).
- • Creatine Monohydrate has a slightly cleaner safety profile.
Side-by-side traits
| Trait | Creatine Monohydrate | Methylfolate (5-MTHF) |
|---|---|---|
Category | Creatine | Vitamin |
Active compound | Creatine monohydrate | L-5-methyltetrahydrofolate |
Form available | Powder, Capsule | Capsule, Tablet |
Source | synthetic | synthetic |
Typical dose | 3–5 g daily | 400–1000 mcg daily |
Dose range | 3–5 g | 400–1000 mcg |
Loading protocol | Optional: 20 g/day split into 4 doses for 5–7 days | — |
Best taken with | carbohydrates or protein, with water | with food |
Best time of day | any | morning |
Bioavailability How efficiently the body absorbs and utilizes the compound. | Very High (5/5) | Very High (5/5) |
Onset time | Cumulative: saturated in 7–28 days (faster with loading) | Cumulative: 4–8 weeks |
Half-life | ~3 hours (plasma); muscle stores last weeks | ~3 hours |
Evidence level Quality and quantity of human research. | Strong (multiple RCTs / meta-analyses) | Strong (multiple RCTs / meta-analyses) |
Overall effect Subjective effect magnitude. | Very High (5/5) | Low (2/5) |
Muscle / strength | Very High (5/5) | Very Low (1/5) |
Physical energy | High (4/5) | Moderate (3/5) |
Focus / cognition | Moderate (3/5) | Moderate (3/5) |
Mood / stress | Low (2/5) | High (4/5) |
Sleep quality | Very Low (1/5) | Very Low (1/5) |
Immunity | Very Low (1/5) | Low (2/5) |
Recovery Post-exercise recovery support. | High (4/5) | Very Low (1/5) |
Longevity / healthspan | Moderate (3/5) | Moderate (3/5) |
Safety rating 5 = exceptionally well-tolerated; 1 = significant risk profile. | Very High (5/5) | High (4/5) |
Price per serving Approximate USD per typical daily dose. | $0.15 | $0.22 |
Vegan friendly | Yes | Yes |
Gluten free | Yes | Yes |
3rd-party tested | Yes | Yes |
About Creatine Monohydrate
The most studied sports supplement on Earth. Boosts strength, power output and lean mass with a near-perfect safety record.
About Methylfolate (5-MTHF)
Pre-methylated folate that bypasses MTHFR variants. Essential during pregnancy and for treatment-resistant depression with low folate.
Vetted brands, third-party testing, ships worldwide.
Vetted brands, third-party testing, ships worldwide.
Creatine Monohydrate safety
Common side effects:
- • Mild water retention (1–2 lbs)
- • GI upset if taken on empty stomach
Avoid if:
- • Severe kidney disease (consult MD)
Drug interactions:
- • Caffeine (mild dampening)
- • Nephrotoxic drugs
Methylfolate (5-MTHF) safety
Common side effects:
- • Anxiety / irritability (over-methylation)
- • Insomnia (PM use)
Avoid if:
- • Bipolar disorder
Drug interactions:
- • Methotrexate
- • Antiseizure meds
Common uses
- • Muscle gain
- • Strength gain
- • Power output
- • Cognitive support
Stacks well with: Whey Protein Isolate, Beta-Alanine, Caffeine
Common uses
- • Pregnancy
- • MTHFR variants
- • Depression
- • Homocysteine
Stacks well with: Vitamin B12 (Methylcobalamin), Betaine Anhydrous
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Medical disclaimer
SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements — especially if you are pregnant, breastfeeding, take prescription medication, or have a chronic condition.