SupplementDuel

Methylfolate (5-MTHF)

Vitamin

Pre-methylated folate that bypasses MTHFR variants. Essential during pregnancy and for treatment-resistant depression with low folate.

moodMTHFRpregnancyhomocysteine
Typical dose
400–1000 mcg daily
Evidence
Strong (multiple RCTs / meta-analyses)
Onset time
Cumulative: 4–8 weeks
Half-life
~3 hours
Forms
Capsule, Tablet
Source
synthetic
Best taken with
with food
Best time of day
morning
Bioavailability
5/5
Safety rating
4/5
Price per serving
$0.22
Vegan / GF / 3rd-party
✓ / ✓ / ✓
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Common uses

  • • Pregnancy
  • • MTHFR variants
  • • Depression
  • • Homocysteine

Effect profile

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Common side effects

  • • Anxiety / irritability (over-methylation)
  • • Insomnia (PM use)

Avoid if

  • • Bipolar disorder

Drug interactions

  • • Methotrexate
  • • Antiseizure meds

Related vitamin supplements

Methylfolate (5-MTHF) vs Vitamin D3Methylfolate (5-MTHF) vs Vitamin K2 (MK-7)Methylfolate (5-MTHF) vs Vitamin CMethylfolate (5-MTHF) vs Vitamin E (Mixed Tocopherols)Methylfolate (5-MTHF) vs Vitamin B12 (Methylcobalamin)Methylfolate (5-MTHF) vs Biotin (B7)

Medical disclaimer

SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements.