SupplementDuel

Vitamin B12 (Methylcobalamin)

Vitamin

Active 'methylated' form of B12 that bypasses MTHFR variants. Essential for vegans, the elderly, and metformin/PPI users.

energyvegan-essentialMTHFRmethylation
Typical dose
500–1000 mcg daily
Evidence
Strong (multiple RCTs / meta-analyses)
Onset time
Cumulative: 2–8 weeks
Half-life
~6 days
Forms
Tablet, Capsule, Liquid
Source
microbial
Best taken with
sublingual or with food
Best time of day
morning
Bioavailability
5/5
Safety rating
5/5
Price per serving
$0.12
Vegan / GF / 3rd-party
✓ / ✓ / ✓
Find Vitamin B12 (Methylcobalamin)iHerb →

Vetted brands, third-party testing, ships worldwide.

Common uses

  • • Vegan supplementation
  • • Energy
  • • Cognitive function
  • • Anemia

Effect profile

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Common side effects

  • • Generally none

Avoid if

  • • Leber's optic atrophy

Drug interactions

  • • Metformin (depletes)
  • • PPIs (reduces absorption)

Related vitamin supplements

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Medical disclaimer

SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements.