Vitamin B12 (Methylcobalamin) vs Methylfolate (5-MTHF)
Vitamin vs Vitamin · evidence-backed comparison
- • Vitamin B12 (Methylcobalamin) has the broader effect profile across the 9 effect categories.
- • Vitamin B12 (Methylcobalamin) is cheaper per serving ($0.12 vs $0.22).
- • Vitamin B12 (Methylcobalamin) has a slightly cleaner safety profile.
Side-by-side traits
| Trait | Vitamin B12 (Methylcobalamin) | Methylfolate (5-MTHF) |
|---|---|---|
Category | Vitamin | Vitamin |
Active compound | Methylcobalamin | L-5-methyltetrahydrofolate |
Form available | Tablet, Capsule, Liquid | Capsule, Tablet |
Source | microbial | synthetic |
Typical dose | 500–1000 mcg daily | 400–1000 mcg daily |
Dose range | 500–1000 mcg | 400–1000 mcg |
Loading protocol | — | — |
Best taken with | sublingual or with food | with food |
Best time of day | morning | morning |
Bioavailability How efficiently the body absorbs and utilizes the compound. | Very High (5/5) | Very High (5/5) |
Onset time | Cumulative: 2–8 weeks | Cumulative: 4–8 weeks |
Half-life | ~6 days | ~3 hours |
Evidence level Quality and quantity of human research. | Strong (multiple RCTs / meta-analyses) | Strong (multiple RCTs / meta-analyses) |
Overall effect Subjective effect magnitude. | Low (2/5) | Low (2/5) |
Muscle / strength | Very Low (1/5) | Very Low (1/5) |
Physical energy | High (4/5) | Moderate (3/5) |
Focus / cognition | Moderate (3/5) | Moderate (3/5) |
Mood / stress | Moderate (3/5) | High (4/5) |
Sleep quality | Very Low (1/5) | Very Low (1/5) |
Immunity | Low (2/5) | Low (2/5) |
Recovery Post-exercise recovery support. | Low (2/5) | Very Low (1/5) |
Longevity / healthspan | Moderate (3/5) | Moderate (3/5) |
Safety rating 5 = exceptionally well-tolerated; 1 = significant risk profile. | Very High (5/5) | High (4/5) |
Price per serving Approximate USD per typical daily dose. | $0.12 | $0.22 |
Vegan friendly | Yes | Yes |
Gluten free | Yes | Yes |
3rd-party tested | Yes | Yes |
About Vitamin B12 (Methylcobalamin)
Active 'methylated' form of B12 that bypasses MTHFR variants. Essential for vegans, the elderly, and metformin/PPI users.
About Methylfolate (5-MTHF)
Pre-methylated folate that bypasses MTHFR variants. Essential during pregnancy and for treatment-resistant depression with low folate.
Vetted brands, third-party testing, ships worldwide.
Vetted brands, third-party testing, ships worldwide.
Vitamin B12 (Methylcobalamin) safety
Common side effects:
- • Generally none
Avoid if:
- • Leber's optic atrophy
Drug interactions:
- • Metformin (depletes)
- • PPIs (reduces absorption)
Methylfolate (5-MTHF) safety
Common side effects:
- • Anxiety / irritability (over-methylation)
- • Insomnia (PM use)
Avoid if:
- • Bipolar disorder
Drug interactions:
- • Methotrexate
- • Antiseizure meds
Common uses
- • Vegan supplementation
- • Energy
- • Cognitive function
- • Anemia
Stacks well with: Methylfolate (5-MTHF), Betaine Anhydrous
Common uses
- • Pregnancy
- • MTHFR variants
- • Depression
- • Homocysteine
Stacks well with: Vitamin B12 (Methylcobalamin), Betaine Anhydrous
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Medical disclaimer
SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements — especially if you are pregnant, breastfeeding, take prescription medication, or have a chronic condition.