Berberine

Heart

AMPK activator with metformin-like effects on blood glucose and lipids. Powerful but interacts with many medications.

blood-sugarAMPKlipidsmetabolic

Typical dose

500 mg, 2–3× daily with meals

Evidence

Moderate (some RCTs)

Onset time

Cumulative: 4–12 weeks

Half-life

—

Forms

Capsule

Source

plant

Best taken with

with meals

Best time of day

with-meals

Bioavailability

2/5

Safety rating

3/5

Price per serving

$0.40

Vegan / GF / 3rd-party

✓ / ✓ / ✓

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Vetted brands, third-party testing, ships worldwide.

Common uses

• Blood sugar
• Cholesterol
• Insulin sensitivity
• PCOS

Effect profile

Strength

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Muscle

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Energy

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Focus

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Mood

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Sleep

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Immunity

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Recovery

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Longevity

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Common side effects

• GI upset
• Diarrhea
• Constipation
• Cramping

Avoid if

• Pregnancy
• Newborns (jaundice)

Drug interactions

• Many CYP3A4 / CYP2C9 substrates: statins, blood pressure, anticoagulants, diabetes meds

Related heart supplements

Berberine vs CoQ10 (Ubiquinol)

Medical disclaimer

SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements.