SupplementDuel

L-Tryptophan

Sleep

Serotonin and melatonin precursor. Generally safer than 5-HTP for daily use, with strong sleep-onset and mood support.

serotoninmoodsleep-onset
Typical dose
500–1500 mg
Evidence
Moderate (some RCTs)
Onset time
Acute: 60 min
Half-life
~2 hours
Forms
Capsule, Powder
Source
microbial
Best taken with
carbs (improves CNS uptake), empty stomach
Best time of day
evening
Bioavailability
3/5
Safety rating
4/5
Price per serving
$0.35
Vegan / GF / 3rd-party
✓ / ✓ / ✓
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Vetted brands, third-party testing, ships worldwide.

Common uses

  • • Sleep onset
  • • Mood
  • • Carb cravings

Effect profile

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Common side effects

  • • Drowsiness
  • • GI upset
  • • Dry mouth

Avoid if

  • • SSRI use (serotonin syndrome)
  • • Liver disease

Drug interactions

  • • SSRIs
  • • MAOIs
  • • Sedatives

Related sleep supplements

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Medical disclaimer

SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements.