Vitamin E (Mixed Tocopherols) vs Vitamin K2 (MK-7)
Vitamin vs Vitamin · evidence-backed comparison
- • Vitamin E (Mixed Tocopherols) is cheaper per serving ($0.10 vs $0.18).
- • Vitamin K2 (MK-7) has a slightly cleaner safety profile.
Side-by-side traits
| Trait | Vitamin E (Mixed Tocopherols) | Vitamin K2 (MK-7) |
|---|---|---|
Category | Vitamin | Vitamin |
Active compound | α-, β-, γ-, δ-tocopherol | Menaquinone-7 |
Form available | Softgel, Capsule | Softgel, Capsule |
Source | plant | microbial |
Typical dose | 100–400 IU daily | 100–200 mcg daily |
Dose range | 100–400 IU | 100–200 mcg |
Loading protocol | — | — |
Best taken with | fat-containing meal | fat-containing meal |
Best time of day | any | any |
Bioavailability How efficiently the body absorbs and utilizes the compound. | High (4/5) | High (4/5) |
Onset time | Cumulative: 4–8 weeks | Cumulative: 4–12 weeks |
Half-life | ~48 hours | ~72 hours |
Evidence level Quality and quantity of human research. | Moderate (some RCTs) | Moderate (some RCTs) |
Overall effect Subjective effect magnitude. | Low (2/5) | Low (2/5) |
Muscle / strength | Very Low (1/5) | Very Low (1/5) |
Physical energy | Very Low (1/5) | Very Low (1/5) |
Focus / cognition | Very Low (1/5) | Very Low (1/5) |
Mood / stress | Very Low (1/5) | Very Low (1/5) |
Sleep quality | Very Low (1/5) | Very Low (1/5) |
Immunity | Moderate (3/5) | Low (2/5) |
Recovery Post-exercise recovery support. | Low (2/5) | Low (2/5) |
Longevity / healthspan | Moderate (3/5) | High (4/5) |
Safety rating 5 = exceptionally well-tolerated; 1 = significant risk profile. | Moderate (3/5) | High (4/5) |
Price per serving Approximate USD per typical daily dose. | $0.10 | $0.18 |
Vegan friendly | Yes | Yes |
Gluten free | Yes | Yes |
3rd-party tested | Yes | Yes |
About Vitamin E (Mixed Tocopherols)
Fat-soluble antioxidant. Always pick mixed tocopherols, not isolated alpha-tocopherol, to avoid displacing other forms in tissues.
About Vitamin K2 (MK-7)
Activates osteocalcin and matrix-Gla protein to direct calcium into bones rather than arteries. Most evidence comes from the 3-year Rotterdam study.
Vetted brands, third-party testing, ships worldwide.
Vetted brands, third-party testing, ships worldwide.
Vitamin E (Mixed Tocopherols) safety
Common side effects:
- • Bleeding risk (high doses)
Avoid if:
- • Bleeding disorders
- • Surgery (2 weeks before)
Drug interactions:
- • Anticoagulants
- • Statins
- • Chemotherapy
Vitamin K2 (MK-7) safety
Common side effects:
- • Generally none
Avoid if:
- • Warfarin therapy
Drug interactions:
- • Warfarin (major)
- • Other anticoagulants
Common uses
- • Antioxidant
- • Skin health
- • Fertility
Stacks well with: Vitamin C, Fish Oil (Omega-3 EPA/DHA)
Common uses
- • Bone density
- • Arterial health
- • Calcium routing
Stacks well with: Vitamin D3, Magnesium Glycinate
Related comparisons
Medical disclaimer
SupplementDuel is for educational purposes only and is not medical advice. Consult a physician before starting, stopping, or combining supplements — especially if you are pregnant, breastfeeding, take prescription medication, or have a chronic condition.